ICP Mass Spectrometers detect trace and ultra-trace elements by ionizing a sample in argon plasma and separating the resulting ions by mass-to-charge ratio. Detection limits reach parts per trillion across elements from lithium to uranium, and rapid multi-element analysis with a wide dynamic range measures major and trace levels in one run. Collision and reaction cell technology reduces polyatomic interferences, while isotopic ratio measurement supports tracer studies. Blood, urine, tissue and hair samples can be analyzed for trace metals. Typical uses include environmental monitoring, pharmaceutical compliance, food safety, geochemistry, mining and nuclear research.