Automatic Ames Test System LMAAT-A100 – High-Throughput Mutagenicity Screening

What Is Automatic Ames Test System LMAAT-A100?

Automatic Ames Test System LMAAT-A100 is a fully automated instrument that performs the Ames Test to detect whether chemicals cause genetic mutations in bacteria.

It integrates sample preparation, plating, incubation, colony counting, and data analysis, enabling high-throughput and reproducible mutagenicity testing.

Quick Facts 

• Model: LMAAT-A100

• Test Type: Bacterial mutation assay

• Capacity: 240 plates per cycle

• Accuracy: ±0.01 mL dispensing

• Cycle Time: 48–72 hours

• Compliance: OECD TG 471, GLP

What Is LMAAT-A100 Used For?

It is used to detect whether a substance can cause DNA mutations.

Key Applications:

• Pharmaceutical genotoxicity screening

• Chemical and food additive safety testing

• Environmental pollutant analysis

• Academic genetic research

How Does LMAAT-A100 Work?

It measures mutation rates by counting bacterial colonies after chemical exposure.

Process:

1. Automated sample preparation

2. Medium and sample dispensing

3. Exposure to bacterial strains

4. Optional S9 metabolic activation

5. Incubation (controlled temperature)

6. Colony counting via imaging

7. Automated data analysis

Which Industries Use This System?

It is used in labs requiring genetic toxicity testing.

• Pharmaceutical R&D

• Chemical safety labs

• Environmental monitoring agencies

• CROs and academic institutions

Key Features of LMAAT-A100

It offers high precision and full automation for mutagenicity testing.

• 240 tests per cycle

• Multi-strain support (up to 5 strains)

• Automated colony counting

• Integrated software & reporting

• Temperature stability ±0.5°C

• Continuous dish refilling

Why Choose LMAAT-A100?

It improves accuracy, speed, and compliance compared to manual testing.

Benefits:

• Eliminates human error

• High reproducibility

• Faster testing cycles

• Regulatory-ready data

• Scalable high-throughput workflow

Manual vs Automatic Ames System 

Automatic systems provide higher accuracy and throughput than manual methods.

How to Choose the Right Ames Test System?

Choose based on throughput, accuracy, and compliance needs.

Select LMAAT-A100 if:

• You need high-throughput (240 tests/cycle)

• Require multi-strain testing

• Need GLP-compliant workflows

• Want automation + software integration

Can It Detect All Mutation Types?

Yes, it detects both frameshift and base-pair mutations.

Using strains like:

• TA98 → Frameshift mutations

• TA100 → Base-pair substitutions

Frequently Asked Questions 

Q1. What does a positive Ames test mean?
   A positive result means the substance can cause genetic mutations, indicating possible carcinogenic risk.

Q2. Is Ames test required for regulatory approval?
   Yes, it is recommended under OECD guidelines for genotoxicity testing.

Q3. How accurate is LMAAT-A100?
   It provides high precision (±0.01 mL) with automated colony counting, ensuring reproducible results.

Q4. What is S9 metabolic activation?
     It simulates liver metabolism to detect indirect mutagens.

Technical Specifications 

• Capacity: 240 Petri dishes

• Temperature: 0–80°C (±0.5°C)

• Strains: Up to 5

• Power: 220V, 50 Hz

• Dimensions: 1300 × 500 × 600 mm

Executive Summary

Automatic Ames Test System LMAAT-A100 is a high-throughput, fully automated system for bacterial mutagenicity testing.

It enables laboratories to perform accurate, reproducible, and regulatory-compliant genetic toxicology studies, making it ideal for pharmaceutical, chemical, and environmental applications.